Tuesday, June 26, 2012

Create Your Own Product Quickly And Painlessly | Make More Sales

Many marketers avoid product creation because they think it's long and involved and tough to do. We'll discuss a few tried and proven product creation tips so you can take part in this exciting process. Yes, it can be difficult to write about web business processes because you do not know how far to go with explaining everything. For example, if you are reading a tutorial on http://pageonecurator.com, then some amount of knowledge on that subject will be assumed to exist.

You or anybody else can get in trouble if you try to use that in your marketing without fully knowing what to expect or do.

We know you want to do well, so just keep in mind that even the following tips will not be all you need to know or should know. That is one aspect of internet business that we love; there is always something more that can be learned. On the other hand, nothing teaches quite as well as experience, and if you discover something is missing then you will get feedback in some way.

A great product creation tip is to consider your own hobbies, interests and passions. Many of the big online entrepreneurs found success by creating products that revolve around their own hobbies and interests. If you're going to create your own product, work on something that really interests you a lot. For example, if you're interested in "computer programming" and have given a good amount of time to it, it just goes on to show your passion towards it. One of the reasons some people don't succeed with product creation is because they try to make products that they aren't passionate about. However, you have to keep one important thing in mind before you actually jump into product creation and that is to find out if there is a demand for it. You might be really fascinated by your hobby, but there may not be a lot of call for products related to it online.

For instance, if your hobby is "stamp collecting", you can easily write an ebook about it. However, the question that arises here is whether there is a market for such ebook and whether people would spend money to actually buy it. It's important to find the right balance between your passion for a topic and how feasible it will be as a product. Once you know how to get both of these things in one place, there's no looking back. When you're already aware that your product will be potentially successful, it's easier to create. We tend to feel that anytime people are too hasty to consider using new approaches or ideas in their business that they are basically not allowing for maximum growth and revenue. You probably know that a great many will overlook or ignore this encouragement, but all that matters is what you will do or are willing to do. A great many people are far too cynical and skeptical about online marketing methods and maybe even http://guruproductblueprints.com - we do not know. You will always need to carefully assess anything new, though, and that means you have to base your decisions on research, first.

You probably are well aware of the dangers of skipping over checking things out. You know the old saying that most people who buy IM information never use it, and that can easily lead to knowing methods that you have never tried. Online marketers who are impatient or simply do not know are at the greatest risk. It can be frustrating for everybody, but for different reasons, because there are different situations and people can complain about a strategy that is actually good. It is just like locking your car every time you park it, maybe it will never prevent something but one day years from now it could. A membership site has many unique aspects to it, and yes - it can be a product, too. The thing about this kind of product is that there have been so many new products that support membership site creation that it makes them easy to do. A membership site is not looked upon in the same way as a regular website, or blog, and they do create an aura of respectability surrounding you. The members will have a strong feeling of being part of an inner circle, which would be exclusive in more than one way. As a membership site owner, you'll be able to constantly be in touch with your customers, provide value and build long term rapport with them. Also, think about a premium membership for specialty services - many things you can do with that idea. If you want to keep it for the long term, then always look for ways to improve and upgrade/update your content. Membership sites are obviously a continuity program, and some marketers earn excellent monthly revenue from them.

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You can also work on adapting a product from one niche market to another. Let's use an example, try taking an article writing ebook that is for the IM crowd of people. So what you could maybe do with that is use the principles of ebook creation and create a brand new ebook about creating an ebook. The basic idea will be the same because you are dealing with writing in both ebooks. There are many approaches to product creation as you can easily see. Of course we all know that nothing is perfect or applicable for everyone, but for online marketing today's discussion has far-reaching implications. One thing is certain, though, and that is perhaps 99% of any kind of online venture can stand to have more promotional methods put to work. A lot of people can sometimes slip back into a lazier approach to their businesses if they are making solid profits and maybe begin outsourcing work, etc. The history of the net is full of all kinds of stories, and the dangers from getting lazy are very real and not to be taken lightly. Lots of people can take SocialCommissions.com and use it to make money, but only those people who want to truly succeed will not be content with one or two methods of promotion. A successful business will keep you occupied and filled with a positive purpose for as long as you care to stay in the game.

All in all, the product creation tips that we discussed in this article are just a tip of the ice berg. You'll begin to see what else is out there if you stay in the game and keep going.


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Related posts:

  1. How to Create Product Descriptions that Make the Sale
  2. Learn To Create Headlines Like An Expert
  3. Here?s How To Create New Topics For Your Blog
  4. Important Advice For You To Consider When Launching A New Product
  5. How To Create And Manage An Article Directory

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Supreme Court ruling on Arizona law must lead to 'civil discourse' on illegal immigration

The Supreme Court ruling on Arizona law SB 1070 will let states help enforce federal immigration law through police checks on immigration status. This should create more federal-state cooperation in battling illegal immigration, especially in states hit hardest by such massive lawlessness.

By the Monitor's Editorial Board / June 25, 2012

Community members Leticia Ramirez, left, and Jovana Renteria watch the United States Supreme Court decision regarding Arizona's controversial immigration law, SB1070, come down at the Puente Movement offices June 25 in Phoenix.

Matt York/AP Photo

Enlarge

A Supreme Court ruling on Arizona law SB 1070 puts a tight fence around a state?s ability to deal with illegal immigrants. But while asserting a preeminent federal role, the justices nonetheless gave some strong advice: The nation needs a ?searching, thoughtful rational civic discourse? about immigration.

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Indeed serious political discourse on this topic has been lacking even as many states experience an unfair and costly burden because of lapse federal enforcement.

Now with this court decision, Washington must work more closely with the states and carefully tailor a joint responsibility for each state?s particular needs on immigration.

The court upholds the key part of Arizona law SB 1070 ? one that mandates police check the immigration status of someone on suspicion of being in the United States illegally if the person is stopped for another reason.

If all states can now pass such a provision, that will help create more transparency about the extent of illegal immigration ? as well as reveal how often the federal government simply looks the other way in upholding the immigration laws.

The nation needs more openness and accountability about this federal discretion. That will improve the ?civic discourse? and possibly lead to a consensus on how to deal with the 11 million to 12 million illegal immigrants in the US.

The justices left open the possibility that they may restrict a state?s ability to detain someone over immigration status if such detentions are too long. Such an approach reflects the court?s view that states must defer to the power of Congress in setting national immigration policy.

Such deference is difficult, however, for those states hit hard by the high costs of illegal immigrants. The court noted, for example, that unauthorized immigrants make up 8.9 percent of the population of Arizona?s Maricopa County (which includes Phoenix) while being responsible for 21.8 percent of felonies in the county.

Yet the court decided that states cannot impose special actions against either illegal immigrants or employers who hire them.

The uneven impact of illegal migrants across the US requires more federal attention. States cannot be left unprotected in the face of such massive lawbreaking that challenges a state?s ability to govern. Road signs in parts of Arizona, for example, now read: ?DANGER ? PUBLIC WARNING ? TRAVEL NOT RECOMMENDED / Active Drug and Human Smuggling Area.?

At least for the time being, the court will allow greater arrest authority for states on immigration ? although deportation is left up to the federal government. With the legal lines more clearly drawn, Washington must expand enforcement while also welcoming states to join the national effort at defending the border and enforcing immigration laws.

Discourse, after all, is a two-way street.

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Monday, June 25, 2012

Clustering of health behaviours in adult survivors of childhood cancer and the general population.

Source

Institute of Social and Preventive Medicine, Swiss Childhood Cancer Registry, University of Bern, Bern, Switzerland.

Abstract

Background:Little is known about engagement in multiple health behaviours in childhood cancer survivors.Methods:Using latent class analysis, we identified health behaviour patterns in 835 adult survivors of childhood cancer (age 20-35 years) and 1670 age- and sex-matched controls from the general population. Behaviour groups were determined from replies to questions on smoking, drinking, cannabis use, sporting activities, diet, sun protection and skin examination.Results:The model identified four health behaviour patterns: 'risk-avoidance', with a generally healthy behaviour; 'moderate drinking', with higher levels of sporting activities, but moderate alcohol-consumption; 'risk-taking', engaging in several risk behaviours; and 'smoking', smoking but not drinking. Similar proportions of survivors and controls fell into the 'risk-avoiding' (42% vs 44%) and the 'risk-taking' cluster (14% vs 12%), but more survivors were in the 'moderate drinking' (39% vs 28%) and fewer in the 'smoking' cluster (5% vs 16%). Determinants of health behaviour clusters were gender, migration background, income and therapy.Conclusion:A comparable proportion of childhood cancer survivors as in the general population engage in multiple health-compromising behaviours. Because of increased vulnerability of survivors, multiple risk behaviours should be addressed in targeted health interventions.British Journal of Cancer advance online publication, 21 June 2012; doi:10.1038/bjc.2012.250 www.bjcancer.com.

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Predicting treatment response in central nervous system diseases: Simple way of avoiding dangerous side effects?

ScienceDaily (June 23, 2012) ? The commonly-used epilepsy drug, valproic acid (VPA), can have a highly beneficial effect on some babies born with spinal muscular atrophy (SMA), the number one genetic killer during early infancy. But in about two-thirds of such cases it is either damaging or simply has no effect. Now, for the first time, researchers have found a way to identify which patients are likely to respond well to VPA prior to starting treatment. Their results have major implications, not just for SMA patients, but for other conditions treated with the drug such as migraine and epilepsy, and may even provide the conditions for turning VPA non-responders into responders, the researchers say.

Dr. Lutz Garbes, from the Institute of Human Genetics, University of Cologne, Germany, will tell the annual conference of the European Society of Human Genetics on June 24 that he and his colleagues had analysed blood RNA samples from a small group of SMA patients who had been treated with VPA. They found, as expected, that only about one third of patients responded well. In an attempt to discover whether blood sampling was the most appropriate test method to use, they also looked at VPA response in another tissue -- fibroblasts (a type of skin cell). They found that the response in blood and in skin was the same in 60% of cases.

The researchers then generated pluripotent stem cells from fibroblasts of both a VPA responder and a non-responder, and differentiated them into GABAergic neurons (neurons that produce the amino acid GABA, the chief neurotransmitter in the mammalian nervous system). These neurons, when treated with VPA, exhibited a similar response to that previously found in blood and fibroblasts.

"This indicates for the first time that response to VPA is the same among blood and skin and suggests that monitoring blood for VPA therapy is indeed feasible in central nervous system diseases," says Dr. Garbes. "But, even more importantly, by using the SMA patients' fibroblasts we were able to identify a decisive factor in the suppression of the positive response to VPA treatment. Utilising transcriptome-wide microarray profiling*, we found that high levels of the fatty acid transporter protein CD36 are associated with the lack of positive response to treatment.

"The implications of this discovery are far-reaching. First, we have been able to prove that monitoring blood is a reliable method for doctors to determine response to VPA treatment in many central nervous system diseases, since our findings are not specific to SMA. Second, the identification of CD36 as the crucial factor in suppressing response to treatment provides a simple way of appraising whether a patient will respond to therapy before treatment starts. And third, in the long run we may find a way to target CD36 in order to be able to change a non-VPA responder into a responder."

Knowing that CD36 is a crucial factor here means that the current, potentially dangerous, 'trial and error' approach to VPA treatment is now obsolete, the researchers say. Screening of patients for CD36 prior to treatment would mean that only those who would respond positively to VPA would be given it. This is important because, in some cases, VPA can cause life-threatening side-effects such as impairment of liver, blood cell and pancreatic function, especially in those just starting the treatment. "But we still do not understand how CD36 suppresses response to VPA, only that it does so," says Dr. Garbes. "A greater understanding of its effects could also lead to the detection of even better targets to overcome the problem. "

In the case of SMA, VPA works by inhibiting enzymes called histone deacetylase (HDACs) which are involved in regulating the packaging of DNA. HDACs lead to a denser DNA packaging whereby protein production from genes is reduced. Other enzymes called histone acetyltransferases (HATs) lead to a more relaxed DNA structure, producing more protein. By inhibiting HDACs with VPA, the DNA packaging balance shifts towards the more relaxed structure and thus genes get activated and proteins produced. In SMA, the crucial gene is SMN2, a copy gene of the disease-determining gene SMN1. In healthy individuals, SMN1 is the major source of SMN protein, but SMN2 cannot fully compensate for the loss of SMN1 in SMA patients. By increasing SMN2 activity, it will produce more SMN protein and ameliorate the condition.

"Avoiding needless VPA treatment of non-responders would have a major effect on healthcare costs and improve quality of life for patients," Dr. Garbes will say. "Half of the babies born with SMA will die within two years, but the other half can live to twenty or even longer, so this is an important finding for them. Our findings may also help identify patients who are candidates for VPA treatment in many other diseases of the central nervous system, some of them very common.

"In the EU, approximately 550 SMA babies are born each year, and there are about 311,000 new cases of epilepsy per year. It is estimated that, in Europe, migraine affects up to 28% of people at some time in their lives. We are happy that we may have been able to contribute to the development of personalised medicine for so many people," he will conclude.

*A transcriptome-wide microarray profile provides a way of identifying all the genes that are differentially expressed in distinct cell populations or subtypes, allowing the effects of treatment to be monitored.

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The above story is reprinted from materials provided by European Society of Human Genetics (ESHG), via AlphaGalileo.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

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Poll: 1-in-4 uncommitted now in White House race (The Arizona Republic)

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Saturday, June 23, 2012

EURO 2012 LIVE: Germany 1, Greece 0

WARSAW, Poland (AP) ? In the second quarterfinal at Euro 2012, Germany plays Greece on Friday. Here's the best of the action and match-day excitement. All times are local to Poland.

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2151: The players are out for the second half and Germany will get it underway. Two half time changes for Greece, Fanis Gekas and Giorgis Fotakis for Ninis and Tzavellas.

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2137: The statistics don't lie: Germany had 70 percent of possession in the first half. And look at this: Passes completed by the Germans ? 344. Greece? 78. Germany has the lead and the mystery is how it is only by one goal. They have been by far the better side, dominating from the very first minute and have created numerous chances.

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HALF-TIME: Germany 1, Greece 0.

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2130: Germany continues its dominance as it looks to double its lead before half time. Schuerrle cuts in from the left and tries to curl a shot goalwards, but his attempt is deflected out for a corner, which Greece manages to clear.

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2128: It's a fantastic goal from Lahm, but Greece's defending here is abject to say the least. He receives the ball on the left from Khedira and chests the ball down, skips forward and releases a swerving, dipping shot from outside the penalty area into the far corner of the net. Siafkis got a fingertip to it, but the shot was too powerful for him to push it round the post. The Greeks are punished for standing off the left back and Germany deservedly has the lead.

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2124: GOAL! Germany 1, Greece 0 (Lahm).

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2119: Germany coach Joachim Loew looks furious on the sideline at how wasteful his side has been so far, after Reus fires another effort wide from the edge of the penalty area. Is he worried that his decision to drop Podolski, Gomez and Mueller will come back to haunt him?

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2111: This could be a long night for the Greeks. They're pinned back in their half and the Germans are coming forward in waves but just can't hit the target. Klose comes very close to scoring but can't quite stretch far enough to connect with a cross right in front of goal. Merkel, in the stands, has her hands over her mouth looking at that latest missed chance.

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2105: gdunbarap: Torrential rain this morning in Gdansk and most seems to have fallen in the Greece penalty area. Slippery and cutting up badly (via Twitter).

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2102: Giorgos Samaras has become the first player to be shown a yellow card tonight after three robust challenges. He ploughed through Khedira twice before clipping the ankle of Schweinsteiger, and he is eventually booked by the referee with the German captain down and in pain.

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2059: Reus now goes close for Germany. Khedira picks out his forward with a neat first-time through ball and Reus lets fly with a left-footed shot, but drags it wide of the near post.

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2053: The ball is in the back of the net already for Germany, but Klose's effort is ruled out for offside. Khedira hits a low shot at goal from far out and Sofakis spills it out to the midfielder running into the area in anticipation of a mistake, but the flag is raised as the German captain pokes the ball in. Sofakis got clattered as he tried to claim the ball back and is down for a few minutes, but will be OK to continue. Very bright start from Germany, who are passing the ball around nicely.

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2045: And they're underway. Both sets of fans respectfully listen to the national anthems. Tension? What tension?

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2035: Derek Gatopoulos, AP's reporter with the Greek team: "The Greek fans were first to appear in force, a block of about 500 arrived chanting 'Hellas, Hellas'. The atmosphere is overwhelmingly friendly. Again, many Greek fans appear to have traveled from Germany and there were loud boos from them as the German players ran onto the pitch to warm up. They unfurled a giant flag but it was upside down, so they rolled it back up again."

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1955: German coach Joachim Loew must be confident of getting a result tonight! He's dropped his three main forwards, including leading striker Mario Gomez who is replaced by veteran Miroslav Klose. Loew also drops Lukas Podolski and Thomas Mueller, giving Andre Schuerrle and Marco Reus their first starts at the tournament. A fourth change sees Jerome Boateng return as right back after serving a one-match suspension, with Lars Bender returning to the bench.

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1950: Tonight's teams:

Germany: Manuel Neuer, Jerome Boateng, Mats Hummels, Holger Badstuber, Phillipp Lahm, Sami Khedira, Bastian Schweinstiger, Mesut Ozil, Andre Schuerrle, Marco Reus, Miroslav Klose.

Greece: Michalis Sifakis, Giannis Maniatis, Kyriakos Papadopoulos, Sokratis Papastathopoulos, Vasilis Torosidis, Giorgos Tzavellas, Konstantinos Katsouranis, Grigoris Makos, Sotiris Ninis, Dimitrios Salpingidis, Georgios Samaras.

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1930: German Chancellor Angela Merkel will be in the stadium tonight, sitting next to UEFA chief Michel Platini. I wonder how the Greek fans will react when her image is ? inevitably ? beamed up onto the big screen. The new prime minister of Greece, Antonis Samaras, won't be traveling. "The prime minister is a football fanatic and will be watching the game on television," government spokesman Simos Kedikoglou said. He is also due to undergo eye surgery on Saturday.

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1900: Less than two hours to go until the most politically-charged match of Euro 2012 ? and it couldn't have been scripted better. Greece, whose economy has imploded, is up against Germany, which has insisted on deep austerity cuts in return for bailout funds. So much to play for tonight in terms of national pride. The Germans are overwhelming favorites, but the Greeks will be raring to go.

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1845: There is a huge German contingent in Gdansk, but the Greeks are making some serious noise. And the build-up to the match has been peaceful and vibrant around the city.

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1830: The Berlin Morgenpost runs the headline: "Dear Greeks, we're not helping you today!" Inside, there's a cartoon showing a Greek player wearing a German shirt with Germany written across the chest, saying "We're Greece - They're just our sponsors."

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1820: In Germany, the best-selling daily Bild led with: "Bye bye Greece; we can't rescue you today."

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1815: The Greek press is in overdrive for tonight's match. Sports paper 'Derby' shows an ancient Greek warrior clad in full armor and clutching a spear in mid-stride as if charging at the reader, with the headline 'Molon Lave' meaning 'Come and Take it' ? Spartan king Leonidas' famous retort to Xerxes' call to surrender in the battle of Thermopylae.

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1800: From AP's Graham Dunbar in Gdansk: "On Friday, thousands of fans from the two nations at opposite ends of the Eurozone financial crisis are converging on neutral Polish turf for a European Championship quarterfinal match. For Greece fans, Friday's clash in rainy Gdansk inevitably mixes sports and politics, Euro 2012 and the euro currency. They seek respect for their country after its humiliating economic collapse ? and the German government's role in imposing austerity measures."

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Lindsay Lohan's Exhaustion Triggers Investigation Of 'Liz & Dick'

Labor unions monitoring working conditions on the set following reports of exhaustion from cast and crew.
By Kara Warner


Lindsay Lohan as Liz Taylor
Photo:

It's been written many times before, but Lindsay Lohan just can't seem to catch a break. The latest hiccup for the problem-plagued actress involves an on-set investigation of "Liz & Dick," the Lifetime movie in which Lohan is playing a young Elizabeth Taylor.

According to the Wrap, the production is currently under investigation by the labor organizations International Alliance of Theatrical Stage Employees (IATSE) and the actors' union SAG-AFTRA, after multiple reports surfaced of both the cast and crew suffering from exhaustion. One of those reports stemmed from Lohan being found unconscious in her hotel room and rushed to the hospital last Friday (June 15).

"The IATSE is on top of the situation on the set of Lifetime's 'Liz & Dick.' We have had union representatives on the set since last Friday and will continue to monitor the hours and working conditions there," IATSE division director of motion picture and television Mike Miller told the Wrap. "We take very seriously the safety and wellbeing of our crews, and are dedicated to seeing that they are protected from hazardous working conditions."

A spokeswoman for SAG-AFTRA issued a similar statement about investigating the working conditions on the film's set.

"We have thoroughly investigated this matter and our business representatives have visited, and will continue to visit, the set of 'Liz & Dick,' " the SAG-AFTRA rep said. "We have spoken with representatives from the company and they are fully aware of their contractual obligations. We will ensure that all applicable penalties will be paid."

Lohan seemed to make light of the situation via Twitter on Saturday when she issued a very public "note to self."

"Note to self. After working 85hours in 4days, and being up all night shooting, be very aware that you might pass out from exhaustion & 7 paramedics MIGHT show up @ your door," she tweeted. "Hopefully theyre cute. Otherwise it would be a real let down."

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