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US Navy ship-mounted railgun closer to reality, Raytheon and others to make it happen originally appeared on Engadget on Mon, 30 Jan 2012 16:25:00 EDT. Please see our terms for use of feeds.
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Contact: David Orenstein
david_orenstein@brown.edu
401-863-1862
Brown University
PROVIDENCE, R.I. [Brown University] -- First there is the tumor and then there's the horrible question of whether the cancerous cells will spread. Scientists increasingly believe that the structural properties of the tumor itself, such as how tightly the tumor cells are packed together, play a decisive role in the progression of the disease. In a new study, researchers show that the protein Pannexin1, known to have tumor-suppressive properties, plays an important role in keeping the cells within a tissue closely packed together, an effect that may be lost with cancer.
"In healthy tissues, the recently discovered protein Pannexin1 may be playing an important role in upholding the mechanical integrity of the tissue," said first author and Brown University M.D./Ph.D. student Brian Bao. "When we develop cancer, we lose Pannexin1 and we lose this integrity."
The results appeared in advance online in the Journal of Biological Chemistry on Jan. 20.
To conduct their research, the group at Brown University and the University of British Columbia employed a "3-D Petri dish" technology that allows investigators to watch closely how cells interact with each other, without scientists having to worry about additional interactions with surrounding scaffolding or the culture plate itself. How readily the cells form large multicellular structures therefore reflects their interactions with each other, not their in vitro surroundings.
Bao's advisor, Jeffrey Morgan, associate professor of medical science, developed the 3-D Petri dish technology. Morgan is the paper's senior author.
Cancer cells converge
Starting with rat "C6" glioma (brain tumor) cells that do not express Pannexin1, the researchers left some unaltered and engineered others to express Pannexin1. After putting the different cells into the 3-D Petri dishes and watching them interact for 24 hours, they saw that the Pannexin1 cells were able to form large multicellular tissues much faster and more tightly than the unaltered cancer cells.
To confirm that Pannexin1 was indeed causing these changes, Bao and his colleagues treated their samples with the drugs Probenecid and Carbenoxolone, which are well known inhibitors of Pannexin1. They saw that sure enough, the drugs negated Pannexin1's accelerating effect.
Then the team was ready to achieve the the study's main aim, Bao said, namely to determine how Pannexin1 was able to drive these cells to clump together faster and tighter. They found that Pannexin1 sets off a chain reaction involving the energy-carrying molecule ATP and specific receptors for it.
When all experiments were done, Bao, Morgan, and their collaborators had found that as soon as the cells touched each other, Pannexin1 channels were stimulated to open and release ATP. The ATP then bound to cell surface receptors, kicking off intracellular calcium waves that ultimately remodeled the network of a structural protein called actin. This remodeling increases the forces between the cells, driving them to bind together more tightly.
Figuring out that sequence, and Pannexin1's role in it, is perhaps the study's biggest contribution to cancer research, Bao said.
"Using their single-cell systems, others have been able to carefully study individual pieces of this cascade," he said. "We came from a different perspective. Because the strength of our assay is that we can look at gross multicellular behavior in 3-D, we could ask, 'Does this actually manifest into something tangible on the multicellular level?'"
Having gained this understanding of Pannexin1's role in the mechanics of tumors, Bao is now engaged in research to answer the obvious next questions: Does Pannexin1 affect the tumor's ability to spread and invade? When cancerous cells regain Pannexin1 expression, are they less likely to spread and leave the tumor?
###
The paper's other authors include Christian Naus from the University of British Columbia and Charles Lai, currently at HarvardMassachusetts General Hospital.
The U.S. National Institutes of Health and the Canadian Institutes of Health Research funded this work.
?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Contact: David Orenstein
david_orenstein@brown.edu
401-863-1862
Brown University
PROVIDENCE, R.I. [Brown University] -- First there is the tumor and then there's the horrible question of whether the cancerous cells will spread. Scientists increasingly believe that the structural properties of the tumor itself, such as how tightly the tumor cells are packed together, play a decisive role in the progression of the disease. In a new study, researchers show that the protein Pannexin1, known to have tumor-suppressive properties, plays an important role in keeping the cells within a tissue closely packed together, an effect that may be lost with cancer.
"In healthy tissues, the recently discovered protein Pannexin1 may be playing an important role in upholding the mechanical integrity of the tissue," said first author and Brown University M.D./Ph.D. student Brian Bao. "When we develop cancer, we lose Pannexin1 and we lose this integrity."
The results appeared in advance online in the Journal of Biological Chemistry on Jan. 20.
To conduct their research, the group at Brown University and the University of British Columbia employed a "3-D Petri dish" technology that allows investigators to watch closely how cells interact with each other, without scientists having to worry about additional interactions with surrounding scaffolding or the culture plate itself. How readily the cells form large multicellular structures therefore reflects their interactions with each other, not their in vitro surroundings.
Bao's advisor, Jeffrey Morgan, associate professor of medical science, developed the 3-D Petri dish technology. Morgan is the paper's senior author.
Cancer cells converge
Starting with rat "C6" glioma (brain tumor) cells that do not express Pannexin1, the researchers left some unaltered and engineered others to express Pannexin1. After putting the different cells into the 3-D Petri dishes and watching them interact for 24 hours, they saw that the Pannexin1 cells were able to form large multicellular tissues much faster and more tightly than the unaltered cancer cells.
To confirm that Pannexin1 was indeed causing these changes, Bao and his colleagues treated their samples with the drugs Probenecid and Carbenoxolone, which are well known inhibitors of Pannexin1. They saw that sure enough, the drugs negated Pannexin1's accelerating effect.
Then the team was ready to achieve the the study's main aim, Bao said, namely to determine how Pannexin1 was able to drive these cells to clump together faster and tighter. They found that Pannexin1 sets off a chain reaction involving the energy-carrying molecule ATP and specific receptors for it.
When all experiments were done, Bao, Morgan, and their collaborators had found that as soon as the cells touched each other, Pannexin1 channels were stimulated to open and release ATP. The ATP then bound to cell surface receptors, kicking off intracellular calcium waves that ultimately remodeled the network of a structural protein called actin. This remodeling increases the forces between the cells, driving them to bind together more tightly.
Figuring out that sequence, and Pannexin1's role in it, is perhaps the study's biggest contribution to cancer research, Bao said.
"Using their single-cell systems, others have been able to carefully study individual pieces of this cascade," he said. "We came from a different perspective. Because the strength of our assay is that we can look at gross multicellular behavior in 3-D, we could ask, 'Does this actually manifest into something tangible on the multicellular level?'"
Having gained this understanding of Pannexin1's role in the mechanics of tumors, Bao is now engaged in research to answer the obvious next questions: Does Pannexin1 affect the tumor's ability to spread and invade? When cancerous cells regain Pannexin1 expression, are they less likely to spread and leave the tumor?
###
The paper's other authors include Christian Naus from the University of British Columbia and Charles Lai, currently at HarvardMassachusetts General Hospital.
The U.S. National Institutes of Health and the Canadian Institutes of Health Research funded this work.
?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Source: http://www.eurekalert.org/pub_releases/2012-01/bu-ilp013012.php
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Lindsay Lohan Fires Back Against Rehab Employee Lawsuit
Lindsay Lohan is hitting back at claims she assaulted a Betty Ford Center staff member in 2010, filing a legal response to Dawn Bradley’s claims. [...]
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A Second Take on Meeting the Press: From an up-close look at Rachel Maddow's sneakers to an in-depth look at Jon Krakauer's latest book ? it's all fair game in our "Meet the Press: Take Two" web extra. Log on Sundays to see David Gregory's post-show conversations with leading newsmakers, authors and roundtable guests. Videos are available on-demand by 12 p.m. ET on Sundays.
Source: http://www.msnbc.msn.com/id/3032608/vp/46180827#46180827
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WASHINGTON, DC (Reuters) ? In his final act before departing the Securities and Exchange Commission on Friday, the agency's inspector general, David Kotz, criticized how the agency analyzes the economic impact of some of its Dodd-Frank rules.
Kotz's criticism, contained in a report, could have ramifications for the SEC, which has lost several court battles over the years because of flaws in how it demonstrates that the benefits of a rule outweigh its costs.
"We found that the extent of quantitative discussion of cost-benefit analyses varied among rulemakings," Kotz wrote in his report. "Based on our examination of several Dodd-Frank Act rulemakings, the review found that the SEC sometimes used multiple baselines in its cost-benefit analyses that were ambiguous or internally inconsistent."
Last year, U.S. business groups successfully convinced a federal appeals court to overturn one of the SEC's Dodd-Frank rules that aimed to empower shareholders to more easily nominate directors to corporate boards.
In rejecting the rule, the court said the agency failed to properly weigh the economic consequences.
Some of the business groups, such as the U.S. Chamber of Commerce, have since raised similar concerns with other rulemakings pending before the SEC.
Congress passed the Dodd-Frank act in 2010 to more closely police financial markets and institutions after the 2007-2009 financial crisis. The legislation gives the SEC responsibility to write roughly 100 new rules.
Although the SEC is not subject to an express statutory requirement to conduct a cost-benefit analysis of its rules, other laws do require the agency to consider the effects of its rules on capital formation, competition and efficiency.
In addition, the SEC must also follow federal rulemaking procedures, such as providing the public with an opportunity to comment on its proposals.
This is the second report Kotz has issued looking at the quality of the SEC's cost-benefit analysis.
Both reports were issued after certain members of the Senate Banking Committee, including ranking Republican Richard Shelby, voiced concerns about whether regulators were adequately examining the economic impact of Dodd-Frank rules.
To determine how well the SEC is faring, Kotz's office retained Albert Kyle, a finance professor at the University of Maryland's Robert H. Smith School of Business, to help carry out the review.
Friday's report covered a sample of Dodd-Frank rulemakings, including a rule allowing shareholders a non-binding vote on compensation, several asset-backed securities rules and two proposals pertaining to the reporting of security-based swap data.
Kotz's report was critical of the agency in a number of areas.
In one instance, the report cites a memo in which former General Counsel David Becker gave his opinion that the SEC should do thorough cost-benefit analyses on rules that are not explicitly required by Congress.
Rules mandated by Congress, however, generally would not need the same level of cost-benefit research, the memo said.
The report suggested that the agency should reconsider these guidelines, or else it risks "not fulfilling the essential purposes of such analyses."
SEC management, in a written response to the report, disagreed with that point.
"We believe Professor Kyle's opinion fails to appreciate both the practical limitations on the scope of cost-benefit a regulator can conduct, and the distinct roles of Congress and administrative agencies," they said.
"We think it is entirely sensible ... for the staff to focus its attention and the commission's limited resources on matters that the commission has the authority to decide."
Kotz made other recommendations, including using a single consistent baseline in the cost-benefit analysis process and having economists provide more input.
SEC spokesman John Nester declined to comment beyond the SEC comments in the report.
(Reporting By Sarah N. Lynch; Editing by Steve Orlofsky, Gary Hill)
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updated 5:58 p.m. ET Jan. 28, 2012
LONDON - Liverpool reached the fifth round of the FA Cup on Saturday at the expense of its fiercest rival, a last-gasp 2-1 victory over Manchester United leaving the famous competition without the English Premier League's top two teams.
While Chelsea progressed with a 1-0 win at Queens Park Rangers thanks to Juan Mata's second-half penalty, Netherlands forward Dirk Kuyt scored the winner for Liverpool in the 88th minute at Anfield.
United earlier dumped out neighbor Manchester City ? the Premier League leader and defending FA Cup champion ? in the fourth round, leaving the world's oldest club knockout competition wide open this year.
Second-tier Brighton beat Premier League Newcastle 1-0 at Amex Stadium in another Cup match that Magpies defender Mike Williamson will want to forget.
Williamson deflected in Will Buckley's close-range effort for the only goal 14 minutes from time. The defender also scored an own goal last season when Newcastle lost to then League Two side Stevenage in the third round of the competition.
Bolton beat Swansea 2-1 and Norwich won by the same scoreline at West Bromwich Albion in the other all-Premier League matchups, while Stoke ? which lost the 2011 final to Man City ? also progressed with a 2-0 win at Derby.
Arsenal hosts Aston Villa on Sunday.
Liverpool and United met for the first time since the unsavory race row between Luis Suarez and Patrice Evra erupted in a Premier League match between them in October.
Evra, United's captain on Saturday, was booed throughout while Suarez watched from the stands as he served the seventh of his eight-game ban for repeatedly racially abusing the France defender.
The match passed without trouble, however, with United manager Alex Ferguson saying: "The players showed great respect to each other ? there wasn't a bad tackle in the game."
Denmark center back Daniel Agger's opener for Liverpool in the 21st minute was canceled out by United's Park Ji-sung six minutes before the break in a first half edged by the visitors, despite being without a raft of key players including the injured Wayne Rooney.
Kuyt settled the match when he ran to a flick-on by Andy Carroll and beat United goalkeeper David de Gea at the near post.
___
BARCELONA, Spain (AP) ? Three days after Barcelona ended its Copa del Rey title defense, Real Madrid came from behind to beat last-place Zaragoza 3-1 on Saturday as its campaign rolled on to break its fierce rival's hold on the Spanish league title.
Three days after Barcelona ended Real Madrid's Copa del Rey title defense, the Spanish champions' own hopes of a fourth successive league dimmed after a 0-0 draw at Villarreal on Saturday.
Barcelona's slip let Madrid move seven points clear of its fierce rival just past the season's midway point through its earlier 3-1 comeback win over last-place Zaragoza.
Lionel Messi missed with a chip shot early, and Cesc Fabregas hit the crossbar late in Barcelona's best scoring chances.
Zaragoza, which upset Madrid at home late last season, started well with Angel Lafita scoring an 11th-minute opener.
But Kaka leveled for Madrid in the 32nd, and Cristiano Ronaldo and Mesut Oezil added two more shortly after halftime at Santiago Bernabeu Stadium.
Ronaldo has scored in each of Madrid's last four games, and his 24 league goals are best in Spain, two ahead of Barcelona's Lionel Messi, who was playing later Saturday against Villarreal.
Madrid has won nine of 10 league home games this season, with its only home loss to Barcelona in December.
"Every game is tough. Zaragoza is a good team and they showed it with a quick goal," Madrid midfielder Esteban Granero said. "But we gave it our all and were able to turn it around."
After his team's strong performance in its closely fought elimination by Barcelona on Wednesday, Madrid coach Jose Mourinho opted again for an attack-minded starting 11 with rarely used Granero and Kaka in midfield behind Oezil and scoring pair Karim Benzema and Ronaldo.
Fernando Llorente scored a hat trick to give Athletic Bilbao a 3-2 win at Rayo Vallecano.
After Miguel "Michu" Perez's opener for Rayo, Llorente headed in a free kick to level in the 16th minute, and added a second when he controlled a pass with his chest, spun and fired from the edge of the area in the 23rd.
Alejandro Arribas drew Rayo even moments later, but Llorente headed home Gaizka Toquero's cross for the 68th-minute winner and his 11th league goal of the season.
Bilbao, which plays third-tier Mirandes in the Copa del Rey semifinals this week, moved into sixth place.
Also, Espanyol edged 10-man Mallorca 1-0 to climb level on points with fourth-place Levante.
___
BERLIN (AP) ? Bayern Munich beat Wolfsburg 2-0 to remain top of the Bundesliga on goal difference, just ahead of Borussia Dortmund and Schalke.
All three are tied at 40 points, but Bayern will be looking nervously over its shoulder after Dortmund brushed Hoffenheim aside 3-1 and then Schalke came from behind to win 4-1 in Cologne.
American Fabian Johnson scored his second goal of the season for Hoffenheim, and his first in the Bundesliga since Dec. 5, 2009. His other goal this season was in the German Cup last July 31.
Dortmund was already 3-0 up at home through two goals from Shinji Kagawa and another from Kevin Grosskreutz, before league scoring leader Mario Gomez's 60th-minute strike allowed Bayern a sigh of relief.
Dutch winger Arjen Robben sealed the points in an edgy win for Bayern with a goal in injury time.
"We had a lot of chances and for me this win is fully deserved," Bayern coach Jupp Heynckes said. "The win gives us security so we can continue like this in the coming weeks."
Werder Bremen drew 1-1 with Bayer Leverkusen, Hamburger SV won 2-1 at Hertha Berlin, and Augsburg and Kaiserslautern played out a 2-2 draw in a relegation battle.
___
MILAN (AP) ? Juventus' charge towards the Serie A title gathered pace with a 2-1 win over third-place Udinese in falling snow on Saturday.
Alessandro Matri scored either side of Antonio Floro Flores' equalizer to help unbeaten leader Juventus move four points clear of second-placed AC Milan, which faces Cagliari on Sunday.
Udinese was two points further back and could be caught by Inter Milan, which visits Lecce on Sunday.
"I was worried a lot about this game because Udinese is a team which plays very interesting football and has a lot of talented players who make up a great team," Juve coach Antonio Conte said.
"Towards the end we were obviously tired after the Italian Cup, but we controlled the game well and got an important win. However, today we lost too many balls in midfield and so gave Udinese too much space to counterattack."
Catania was held to 1-1, a result which did neither team any favors in the standings.
Gonzalo Bergessio gave Catania a deserved lead shortly after the half-hour mark, but Francesco Modesto leveled 10 minutes later.
The tie left Parma nine points above the relegation zone before the rest of the weekend's fixtures. Catania, which has won only one of its past seven games, was tied with Cagliari a point further back.
___
PARIS (AP) ? Big-spending Paris Saint-Germain needed a scrappy 1-0 win over Brest to keep a three-point lead over Montpellier at the top of the French league.
PSG defender Milan Bisevac flicked home a corner from Christophe Jallet in the sixth minute.
Brest lost its first home match this season while PSG has now won all four games under coach Carlo Ancelotti, who replaced Antoine Kombouare last month.
Also Saturday, it was: Nice 0, Montpellier 1; Lyon 3, Dijon 1; Toulouse 1, Caen 0; Lorient 1, Sochaux 1; and Auxerre 1, Nancy 3.
Lille hosts Saint-Etienne later Saturday.
___
ATHENS, Greece (AP) ? Olympiakos closed within two points of Greek league leader Panathinaikos by defeating stubborn visitor Ergotelis 3-0.
Ergotelis ended the game with nine players, as Mario Hieblinger and Andreas Bouhalakis were shown second yellow cards for rough challenges in the 56th and 60th minutes, respectively.
Also, OFI beat Xanthi 1-0 and Panionios defeated Kerkyra 2-0.
Panathinaikos travels to last-place Drama on Sunday.
___
GLASGOW, Scotland (AP) ? Rangers kept the pressure on Scottish Premier League leader Celtic with a 4-0 thrashing of 10-man Hibernian.
Captain Steven Davis scored two goals.
Celtic, whose lead was trimmed to one point, was not in league action this weekend. Instead, Neil Lennon's team will face Falkirk in the semifinal of the Scottish League Cup on Sunday.
Motherwell tightened its grip on third place, six points ahead of Hearts, by beating St. Johnstone 3-2.
Copyright 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
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More newsAbby Wambach and Christine Sinclair have spent the last two weeks chasing each other, chasing history and chasing a place in the London Olympics.
Euro roundup: Liverpool reaches the 5th round of the FA Cup, beating rival Manchester United 2-1.
Source: http://nbcsports.msnbc.com/id/46175745/ns/sports-soccer/
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LOS ANGELES (Reuters) ? Late pop star Michael Jackson was immortalized in cement on Thursday when his three children stamped the "Thriller" singer's glove and shoe prints in the hallowed concrete courtyard of Grauman's Chinese Theater in Hollywood.
Well over a hundred fans of the King of Pop and celebrities including Justin Bieber and Jackson family members watched the song and dance spectacle and listened to the three children talk about the legacy of their father.
"My dad won the lifetime achievement award. It was an award he strived and worked the hardest to get but for me, and I think for him as well, this right here is his lifetime achievement award. This is what he strived to get and this is what we are giving him now today," said Prince Michael, 14, Jackson's eldest son.
Jackson's daughter Paris, 13, imprinted her father's iconic silver sequined glove and scrawled his name into the cement, adding a heart in between Michael and Jackson. Prince Michael and his brother Blanket, 9, put their father's shoe into the cement, and all three left their own handprints next to dad's.
The hour-long ceremony included spoken tributes and musical performances from Jackson's friends and family, including his brothers Tito and Jackie, who were part of the Jackson 5, and mother Katherine who called the event "a very very solemn occasion for my son."
"Michael, we miss you, that's for sure. There's hardly a day that goes by without him going on in my mind somehow, some way, and I know he is here today with us," said Tito Jackson.
Musical producer Quincy Jones, who worked with Jackson on one his most successful album, "Thriller," Motown singer Smokey Robinson and comedian Chris Tucker, a friend of Jackson's, shared their personal memories of Jackson while Canadian pop sensation Bieber called him "an inspiration."
"People are going to remember him for his dancing and his singing, but people need to remember him for who he was," said Bieber.
"Everything I do, I look at Michael and I want to be as good as he was," said Bieber, 17, whose rise to fame was compared to the late singer by Paris as she introduced him.
Jackson gained success with songs such as "ABC" and "I'll Be There" as a child singer with his brothers, and later pursued a solo career that earned him worldwide fame and fans with hits such as "Rock With You," "Bad," and "Beat It."
His sudden death from a drug overdose in 2009 aged 50, sent shockwaves around the world. Late last year, Jackson's doctor at the time was convicted of involuntary manslaughter for administering a surgical anesthetic to Jackson as a sleep aid.
Jackson's glove and shoe imprints will be placed alongside Hollywood screen legends such as Clark Gable, Marilyn Monroe and Sidney Poitier outside the iconic Hollywood theater that has been a tourist attraction for decades.
Notably absent from the ceremony were Jackson's sisters Janet and LaToya as well as brothers Jermaine and Randy.
The event, hosted by the late singer's estate, showcased dancers from Cirque du Soleil's Jackson tribute show and featured "Glee" cast member Harry Shum, Jr. ahead of the show's Jackson tribute episode next week.
(Reporting By Piya Sinha-Roy; Editing by Bob Tourtellotte)
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ScienceDaily (Jan. 26, 2012) ? Researchers from the University of Medicine and Dentistry of New Jersey (UMDNJ) and Columbia University have discovered that the most common receptor for the major neurotransmitter in the brain is also present in the lens of the eye, a finding that may help explain links between cataracts, epilepsy and use of a number of widely prescribed antiepileptic and antidepressant drugs. The research appears online in Biochemical and Biophysical Research Communications.
"Recent studies identified associations between increased cataracts and epilepsy, and showed increased cataract prevalence with use of antiepileptic drugs as well as some common antidepressants," explained corresponding author Peter Frederikse, PhD, of the UMDNJ-New Jersey Medical School. "One common theme linking these observations is that our research showed the most prevalent receptor for the major neurotransmitter in the brain is also present in the lens."
The research team, which included Norman Kleiman, PhD, of the Mailman School of Public Health at Columbia University, with Mohammed Farooq of the New Jersey Medical School and Rajesh Kaswala, DDS, and Chinnaswamy Kasinathan, PhD, from the New Jersey Dental School, found these glutamate receptor proteins, and specifically a pivotal GluA2 subunit, are expressed in the lens and appear to be regulated in a surprisingly similar manner to the way they are in the brain. In the nervous system, glutamate and GluA receptor proteins underlie memory formation and mood regulation along with being an important factor in epilepsy, considered a primary disorder of the brain. Consistent with this, these receptor proteins are also targets for a number of antiepileptic drugs and antidepressant medications.
"The presence of these glutamate receptors in the lens suggests they contribute to links between brain disease and cataract, as well as providing unintended secondary 'targets' of current drugs," Frederikse said. "Our goal now is to use this information to parse out the potential effects of antiepileptics and antidepressants on these 'off-target' sites in the lens, and to determine the role glutamate receptors have in lens biology and pathology."
This research was supported by a grant from the National Eye Institute of the National Institutes of Health.
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LONDON ? A British court has banned a man from driving for a year after he was caught traveling with four children in the trunk of his car.
Britain's Press Association news agency said Thursday that police found a total of 11 people in Zoltan Lakatos' Audi A4 when they stopped him in the English city of Leicester last year.
One passenger was in the driver's seat, three adults and two children were squeezed into the back, and officers discovered four more children in the trunk.
The news agency says Lakatos was convicted of endangering his passengers and of driving without insurance earlier this week at Leicester Magistrates' Court. He also was fined 1,325 pounds (about $2,080).
The agency said the 38-year-old was not in court for the ruling.
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DAMASCUS (Reuters) ? Arab League monitors said the withdrawal of colleagues by Gulf Arab states would not hinder their work in Syria while France and Britain Wednesday joined efforts at the United Nations to end President Bashar al-Assad's rule.
"The U.N. Security Council must support the Arab League's courageous decisions which are trying to end the repression and violence in Syria and find a solution to the political crisis," French Foreign Ministry spokesman Bernard Valero said.
"Our aim is to get a resolution approved." The Security Council could vote as early as next week on a Western-Arab draft resolution, council diplomats said.
U.S. President Barack Obama said in his State of the Union address that Assad would "soon discover that the forces of change can't be reversed."
Russia's Foreign Minister Sergei Lavrov said his country remained opposed to sanctions on Syria and reiterated its opposition to military intervention.
But it is unclear whether Russia is prepared to wield its veto powers again to block council action on Syria.
More than 50 observers from Gulf Arab states left Syria on Wednesday after their governments said they were certain "the bloodshed and killing of innocents would continue."
Their colleagues in Damascus, about 120 strong, pledged to continue the monitoring mission, now extended until February 23, to verify Syria's compliance with an earlier Arab peace plan.
"The departure of the GCC (Gulf Cooperation Council) countries will not have an impact on the mission's work. We are all professionals here and we can do the job," said a senior Arab monitor, who asked not to be named.
"We need more monitors of course and more will come soon to replace those who left."
Syrian opposition groups have accused the observer mission, which began on December 26, of giving Assad diplomatic cover to pursue a crackdown on protesters and rebels in which more than 5,000 people have been killed since March, by a U.N. tally.
Arab League chief Nabil Elaraby and Qatari Prime Minister Hamad bin Jassim al-Thani, who heads the League's committee on Syria, wrote jointly to U.N. Secretary General Ban Ki-moon setting out their plan for a political solution in Syria.
Several diplomats at the United Nations said France and Britain were working with Qatar and other Arab delegations on a new draft resolution supporting the Arab League plan which envisages Assad stepping down and making way for a unity government to halt the bloodshed of a 10-month uprising.
Valero said the talks should enable the Security Council to support and enforce the Arab plan by giving it the necessary international guarantees for it to be implemented.
"TERRORISTS"
The head of the Syrian Arab Red Crescent in the northern town of Idlib was shot dead Wednesday, the International Committee of the Red Cross said, in an attack which Damascus blamed on "terrorists."
State news agency SANA also said a priest was killed by "terrorists" while helping a wounded person in the city of Hama.
The government says it is fighting foreign-backed Islamist "terrorists" who have killed 2,000 soldiers and police. SANA said 30 more were buried in the last two days.
The British-based Syrian Observatory for Human Rights said seven other people were killed Wednesday. One was killed by soldiers surrounding the Bab Qabli district of Hama and a woman died after a shell landed on her house near the town of Qusair, 10 km from the Lebanese border, it said.
It also reported clashes between army deserters and state soldiers in the rebellious province of Idlib that disabled three armored vehicles and killed or wounded six soldiers.
The revolt in Syria was inspired by other uprisings that have toppled three autocratic Arab leaders over the past year and the bloodletting has battered Assad's standing in the world.
The Arab League has suspended Syria's membership and Iran, at loggerheads with Western powers over its disputed nuclear ambitions, is among Assad's few remaining allies.
Foreign Minister Walid al-Moualem wrote to the Arab League accepting an extension of the monitoring mission. But he rejected the 22-member body's call for Assad to hand power to his deputy and allow a new unity government to prepare for parliamentary and presidential elections.
"TO THE MOON"
"They have abandoned their role as the Arab League and we no longer want Arab solutions to the crisis," Moualem declared on Tuesday. "Heading to the Security Council will be the third stage in their plan, and the only thing left is the last step of internationalization."
Moualem said that while "half the universe is against us" Syria's long-time ally and arms supplier Russia would never permit foreign intervention. "That is a red line for them."
Britain, France and the United States have chastised Moscow for continuing to arm Syria despite the upheaval there.
"The supply of arms and aircraft to the Syrian regime will only fuel bloodshed - which is why the EU has imposed an arms embargo on Syria, and we are calling for the U.N. to do the same," a spokeswoman for the British Foreign Office said.
"All Security Council members, including Russia, need to throw their collective weight behind the Arab League's efforts to stop the violence and achieve a peaceful transition.
"We urge Russia to support these efforts instead of providing cover for a regime's brutal repression."
(Additional reporting by Edmund Blair and Ayman Samir in Cairo, John Irish in Paris and Dominic Evans in Beirut; Writing by Alistair Lyon; Editing by Robert Woodward)
Source: http://us.rd.yahoo.com/dailynews/rss/world/*http%3A//news.yahoo.com/s/nm/20120125/wl_nm/us_syria
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Just because there's a sovereign debt crisis doesn't mean there's no opportunity in Europe, especially if investors are selective and defensive.
Invest in Europe? Now!?
Skip to next paragraphThese days, the idea may seem as inspired as lighting a match to a paycheck. Fund investors appear to be fleeing the debt-troubled continent.
But all that tumult and fear can mask opportunities. For market-savvy investors who want to keep a hand in Europe, there are ways to play the still-economically vital region, some investors and market pros say.
"As long as you are selective and take a two-year investment time horizon, you can find interesting investments," says Stan Pearson, head of European equities at Standard Life Investments, based in Edinburgh, Scotland. "Valuations are quite moderate, and you don't have to pay up" to buy the shares of world-class companies.
Of course, venturing into Europe with its still growing sovereign debt woes requires fortitude. Last year (through Dec. 14), bond funds targeting Europe saw net outflows of $27.7 billion, according to EPFR Global, a Cambridge, Mass., firm that tracks fund flows. European stock funds experienced $11.2 billion in outflows (minus Germany, where the outflow was more than $30 billion). So where do you invest when others are pulling out?
Here are five possible strategies:
1. Buy selected European stocks. Collectively, eurozone stock markets fell almost 20 percent in US dollar terms in 2011. That trimmed the stock prices of world-class European companies that do sizable business outside the eurozone, points out Mr. Pearson. Among those he likes: Ryanair Holdings, based in Dublin, Ireland, a provider of discount air travel; ASML, based in the Netherlands, a world leader in producing machines for making semiconductors; Saipem, headquartered in Milan, Italy, an international provider of oil and gas construction and drilling services; and CFAO, based in France, a major distributor of autos, pharmaceuticals, and other industrial products in Africa and in French overseas territories and communities.
Among the European companies he likes outside the eurozone: Denmark-based Novo Nordisk, a global health-care company.
2. Use Europe to diversify. Portfolios with a globally diversified mix of stocks and high-quality corporate bonds allow the investor or active money manager to choose when and where to invest, says Stephen Wood, chief market strategist at Russell Investments, based in Seattle. Right now, he recommends underweighting European markets versus other regions. But as concerns ebb about the European debt crisis, "disciplined investors will see opportunities in European stocks and bonds, understanding that European government bonds will be problematic for some time to come," he says.
Source: http://rss.csmonitor.com/~r/feeds/csm/~3/OU3mNOnV08E/Five-ways-to-invest-in-Europe-seriously
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Tracy Morgan went from honoree to hospital attendee in Utah last night. But the 30 Rock star should be okay.
The actor fell unconscious soon after accepting an award at the Creative Coalition Spotlight Awards, which was part of the Sundance Film Festival in Park City. He was rushed to a local hospital via ambulance immediately after collapsing.
While initial reports indicated that Morgan was drunk at the event, a spokeswoman for Park City Medical Center tells TMZ no foreign substances were found in the star's system. So, what happened?
"From a combination of exhaustion and altitude, Tracy is seeking medical attention," his rep, Lewis Kay, said in a statement. "He is with his fiance [Megan Wallover] and grateful to the Park City Medical Center for their care. Any reports of Tracy consuming alcohol are 100% false."
[Photo: WENN.com]
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This article originally appeared on The DIV-Net January 16, 2012.
Company Description: Verizon Communications Inc. offers wireline, wireless and broadband services primarily in the northeastern United States. It acquired MCI in 2006 and has since sold or spun off non-core assets. Alltel was acquired in early 2009.
Fair Value: In calculating fair value, I consider the NPV MMA Differential Fair Value along with these four calculations of fair value, see page 2 of the linked PDF for a detailed description:
1. Avg. High Yield Price
2. 20-Year DCF Price
3. Avg. P/E Price
4. Graham Number
VZ is trading at a discount to only 3.) above. Since VZ's tangible book value is not meaningful, a Graham number can not be calculated. The stock is trading at a 41.1% premium to its calculated fair value of $27.17. VZ did not earn any Stars in this section.
Dividend Analytical Data: In this section there are three possible Stars and three key metrics, see page 2 of the linked PDF for a detailed description:
1. Free Cash Flow Payout
2. Debt To Total Capital
3. Key Metrics
4. Dividend Growth Rate
5. Years of Div. Growth
6. Rolling 4-yr Div. > 15%
VZ earned two Stars in this section for 1.) and 2.) above. A Star was earned since the Free Cash Flow payout ratio was less than 60% and there were no negative Free Cash Flows over the last 10 years. The stock earned a Star as a result of its most recent Debt to Total Capital being less than 45%.
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TAMPA, Fla. ? Republican presidential candidate Mitt Romney paid about $3 million in federal income taxes in 2010, having earned more than seven times that from his investments. Those earnings, $21.7 million, put him among the wealthiest of American taxpayers. Romney's campaign said Tuesday he followed all tax laws.
At the same time, Romney gave nearly $3 million to charity ? about half of that amount to the Mormon Church ? which helped lower his effective tax rate to a modest 14 percent, according to records his campaign released early Tuesday.
Romney campaign advisers said Tuesday that the release of more than 500 pages of returns, schedules and worksheets was in "full compliance" with U.S. tax laws and was an effort to provide maximum transparency to the American public.
Romney had refused until recently to disclose any federal tax returns then hinted he would only offer a single year's return in April. But mounting criticism from his rivals and a hard loss in last week's South Carolina primary forced his hand.
For 2011, Romney will pay about $3.2 million with an effective tax rate of about 15.4 percent, the campaign said. Those returns haven't yet been filed yet with the Internal Revenue Service. In total, he would pay more than $6.2 million in taxes over the past two years, his campaign said.
"Gov. Romney has paid 100 percent of what he owes," said Benjamin Ginsberg, a legal adviser to the Romney campaign. Ginsberg and other advisers insisted Romney did not use any aggressive tax strategies to help reduce or defer his tax income.
The advisers acknowledged that Romney continues to earn money from investments from Bain Capital, the Boston-based private equity firm the candidate founded and managed between 1984 and early 1999. Under an agreement with the firm when he left, Romney continued to earn "carried interest" on new Bain investments as a former partner in the firm even though he no longer ran the operation.
Romney earned $7.5 million in Bain earnings in 2010 and expects to make $5.5 million in 2010, Ginsberg said.
The former Massachusetts governor had been cast by his GOP opponents as a wealthy businessman who earned lucrative payouts from his investments while Bain slashed jobs in the private sector. Rival Newt Gingrich made public his 2010 returns on last Thursday, showing he paid almost $1 million in income taxes ? a tax rate of about 31 percent.
Romney's advisers acknowledged Tuesday that Romney and his wife, Ann, had a bank account in Switzerland as part of her trust. The account was worth $3 million and was held in the United Bank of Switzerland, said R. Bradford Malt, a Boston lawyer who makes investments for the Romneys and oversees their blind trust, which was set up to avoid any conflicts of interest in investments during his run for the presidency.
In 2009, UBS admitted assisting U.S. citizens in evading taxes, and agreed to pay a $780 billion penalty as part of a deferred prosecution agreement with the U.S. Justice Department.
Malt said the account was closed for "diversification" in early 2010. He said he made the decision to close the Swiss account because it "just wasn't worth it." Malt sidestepped a question about whether he closed the account because it could be a political liability, saying it "might or might not be inconsistent with Gov. Romney's political views." Malt has sold off other accounts in recent years ? including investments in firms that did business with Iran and China ? because of possible political inconsistency or embarrassment with Romney's political positions.
Malt also confirmed that some of Romney's investments are routed through affiliate funds set up in the Cayman Islands. But he insisted there were no actual offshore accounts, and added that Romney paid the same amount of U.S. taxes using the Cayman affiliates as he would have if the investment funds were set up in the U.S.
Romney's campaign confirmed the details of his tax information after several news organizations saw a preview of the documents. He had said he planned to release his returns in full Tuesday morning, and campaign officials would be prepared to discuss them in detail with reporters.
"You'll see my income, how much taxes I've paid, how much I've paid to charity," Romney said during Monday night's debate in Tampa. "I pay all the taxes that are legally required and not a dollar more. I don't think you want someone as the candidate for president who pays more taxes than he owes."
Romney's 2010 returns show the candidate is among the top 1 percent of taxpayers. The returns showed about $4.5 million in itemized deductions, including $1.5 million to the Church of Jesus Christ of Latter-Day Saints.
Before the tax records were released, Romney's old investments in two government-backed housing lenders stirred up new questions at the same time his campaign targeted Gingrich for his work for Freddie Mac.
Gingrich earned $1.6 million in consulting fees from Freddie Mac. Romney has as much as $500,000 invested in the U.S.-backed lender and its sister entity, Fannie Mae.
The fight over releasing the tax information highlighted an argument that Democrats are already starting to use against Romney ? that he is out-of-touch with normal Americans. And it probably hurt him in the South Carolina primary, where he lost by 12 percentage points to Gingrich after spending several days resisting calls to release the returns.
In Monday's debate, Romney would not answer questions from moderator Brian Williams of NBC about just what pieces of his tax returns could cause political headaches. But they will shine the spotlight on a fortune estimated at between $190 million and $250 million, and could raise questions about where he keeps his money and how he earns it.
But it's clear that Romney's campaign is bracing for an onslaught of criticism of his personal fortune. His wife, Ann, has started talking about the returns during campaign appearances. She told supporters at a Florida rally Sunday: "I want to remind you where we know our riches are. Our riches are with our families."
Most of Romney's vast fortune is held in a blind trust that he doesn't control. A portion is held in a retirement account.
___
Braun and Associated Press writers Jack Gillum and Stephen Ohlemacher reported from Washington.
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www.uinterview.com:
If you grew up in the United States of America, you probably heard the National Anthem about twenty times a year -- at sporting events, on television, Fourth of July, Memorial Day, Veterans' Day. So why, when it comes your time to take the mic and belt out a centuries-old hymn of unbridled patriotism, do you waver? Is it nerves? Overcome with emotion? Hung over from the night before?
Maybe it's because, in the history of singing "The Star-Spangled Banner," more people have messed it up than gotten it right. So, if you've been paying attention, then you're probably pretty confused.
Luckily, we've broken it down for you. The top five ways to screw up the National Anthem follow, with examples of the masters doing it the way it was apparently meant to be done -- totally incorrectly.
Read the whole story: www.uinterview.com
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NEW YORK ? The S&P 500 index eked out a tiny gain Monday while traders kept an eye on talks in Europe to cut Greece's crushing debt load and prevent a global financial crisis. Other indexes ended slightly lower.
The S&P added 0.62 of a point to close at 1,316 on Monday. The broad market measure has now closed higher on 12 of 14 days this year.
European stocks and the euro rose after the continent's finance ministers put pressure on banks that hold Greek government bonds to accept new ones that are worth half as much and carry a lower interest rate.
The Greek stock market gained 5 percent, and indexes in Germany, France, Spain and Britain all advanced less than 1 percent. The euro rose more than a penny to $1.302, close to its highest level against the dollar this year.
Negotiators are trying to prevent a disorderly default by Greece in March. The worst-case scenarios include a credit crisis similar to what happened after the Lehman Brothers investment bank fell in 2008.
The Dow Jones industrial average fell 11.66 points to 12,708.82. That's a loss of 0.1 percent.
The Nasdaq composite index fell 2.53 points, or 0.1 percent, to 2,784.17.
Stocks are still off to a strong start in 2012. Investors' biggest fears have slowly faded. Stronger than expected job growth in the U.S. and falling borrowing costs for European governments have helped send the S&P 500 index up 4.6 percent for the year.
Maybe the biggest boon to markets this year is the lack of scary headlines, said Jeff Lancaster, a principal at the investment firm Bingham, Osborn & Scarborough.
"When everybody is feeling distressed, anxious and worried as they were at the end of last year, it doesn't take a lot of good news for the mood to change," he said. "It just takes a diminishing quantity of bad news."
Many energy stocks jumped along with prices for natural gas and crude oil. Chesapeake Energy Corp., the No. 2 producer of natural gas in the United States, gained 6 percent after it said it plans to cut production, a response to the recent slump in natural gas prices.
Natural gas futures rose 7.9 percent to $2.60 per 1,000 cubic feet. Gas futures were trading above $4 just six months ago.
Stocks of other gas producers shot higher. Southwestern Energy Co. jumped 10 percent, the biggest gain in the S&P 500. Cabot Oil & Gas Corp. was close behind, rising 6.5 percent.
Apache Corp., a producer of oil and gas, rose 1.6 percent after saying said it plans to buy Cordillera Energy Partners in a $2.85 billion deal. It's the largest merger announced in the U.S. this year.
The price of oil rose 1.3 percent to $99.58 per barrel. The European Union tightened sanctions against Iran by banning the purchase of Iranian oil. Iran threatened to block shipping through the Strait of Hormuz, the passageway for one-sixth of the world's oil exports.
Research In Motion Ltd., maker of the BlackBerry, sank 8.5 percent after its new chief executive said no drastic changes are needed. The company's founders announced they were stepping down as co-CEOs late Sunday.
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Ice Cream Sandwich update for original Transformer coming 'mid-February,' says ASUS originally appeared on Engadget on Sat, 21 Jan 2012 15:15:00 EDT. Please see our terms for use of feeds.
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Johnny Depp is America's favorite movie star, according to a new poll released earlier this week. By now, the popularity is par for the course for the eccentric, Oscar-nominated "Pirates" actor, what with his tabloid life and red carpet bows, but he didn't always find fame such a familiar experience.
In this 1988 interview with Entertainment Tonight -- his first with the show -- Depp, who was a 25-year old starring on "21 Jump Street," ruminates on the "strange" venture of being a star in Hollywood.
"You don't expect people to be there, waiting for you, it's very new to me," he says of walking the red carpet. "I'm dealing with it the best way i know how, which is right now, I try to meet as many people as I can and when a situation like they have downstairs with all the kids, I try to sign as many things as I can, I don't want to hurt anybody's feelings or make them feel like I don't have time. But it's very strange time because they're saying, 'Please sign this, please sign this,' and then I have these guard guys pulling me, saying, C'mon, we got to go, we got to go,' so it's a little strange to be in that situation."
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ROME ? Divers are resuming the search of the wreckage of the capsized Costa Concordia after data indicated the cruise ship had stabilized in the sea off Tuscany.
To make it easier to enter and leave, the divers blasted more holes Saturday into the carcass of the ship, which has been lying on its side near the port of Giglio island since shortly after it crashed into a reef Jan. 14
They are searching for bodies or survivors, although it is unlikely any of the 21 missing in the accident could still be alive. The search was suspended on Friday after the Concordia shifted, prompting fears the ship could roll off a rocky ledge of sea bed and plunge deeper into the sea. There are also fears the Concordia's fuel could leak, polluting pristine waters.
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WASHINGTON ? In the 11 days since Mitt Romney tried unsuccessfully to leave the rest of the GOP field behind in New Hampshire, the presidential race has served up a scattershot cast of angels and demons as the candidates try to strike a chord with different slices of the electorate.
Capitalism was in, then out, then in again. Insurance companies got a sideways sympathetic nod. Mike Huckabee and Betty White proved to have some cachet. The press was an ever-popular whipping child.
Europe and entitlements, felons, food stamps and French: All were on the outs with one candidate or another.
Newt Gingrich even ran an ad faulting Romney for his language skills: "Just like John Kerry, he speaks French," it warned ominously.
The GOP challengers went after Romney's venture capitalist credentials with a vengeance ? most memorably when Texas Gov. Rick Perry rebranded him a "vulture capitalist" ? then eased up somewhat when they caught grief from the defenders of free enterprise.
For a little while, even insurance companies ? typically a popular target for politicians of any stripe ? got a little love after Romney said he liked the idea of being able to fire them for poor performance. The other candidates summoned a chorus of outrage at the notion that Romney would relish firing anyone.
Republican strategist Terry Holt said it all adds up to "a blizzard of buzz words" as candidates try to deliver a headline-grabbing quote that will get people's attention.
But does it work?
"Ultimately, it all blends together into a general sense of the candidate," says Holt. "The back-and-forth is lost on most people."
And there's been a lot of back-and-forthing.
Romney and Gingrich both ran ads trying to claim a little luster from popular conservative Huckabee by rolling out nice things he'd said about them. But it turned out Huckabee hadn't endorsed either of them, and both got a scolding from the former Arkansas governor.
President Barack Obama, watching the GOP race from the sidelines, had to be hoping that a little of Betty White's uncanny popularity would rub off when he taped a video piece for her 90th birthday in which he joked that the actress looks so good she should cough up her long-form birth certificate to prove she's really that old.
The GOP candidates trotted out plenty of reliable enemies ? "Obamacare," federal regulations, big government, the Dodd-Frank financial regulations ? but added some new ones to the mix as well.
Gingrich, catering to South Carolina sensibilities and its port communities, singled out the Army Corps of Engineers, complaining in Thursday's debate that the corps "takes eight years to study ? not to complete ? to study doing the port. We won the entire Second World War in three years and eight months."
Candidates' messages zig-zagged all over in search of a winning line that would work with voters.
Earning money was good ? except if your name was Mitt Romney.
A super PAC supporting Gingrich made a half-hour movie attacking Romney for reaping "massive rewards for himself and his investors," complete with sinister music and a baritone-voice narrator.
Romney defended his capitalist credentials by lining himself up with the philosopher known as a father of capitalism, proudly announcing, "Adam Smith was right."
Perry managed to turn the news that U.S. troops had apparently been captured on video urinating on corpses in Afghanistan into an indictment of the Obama administration. The Texas governor accused the Obama team of piling on against "kids" who sometimes make "stupid mistakes."
It didn't do him much good: He was out of the race within days.
Then came the issue of infidelity: Gingrich chose not to comment on the details of his marriage to his second wife after she claimed that he'd asked her for an "open marriage" in which he could have both a wife and a mistress.
Gingrich managed to steer that conversation to the one enemy that all the candidates love to beat up on: the media.
"I think the destructive, vicious, negative nature of much of the news media makes it harder to govern this country," he declared.
But even rival Rick Santorum saw through the tactic, urging voters not to be swept away by Gingrich's blast at the press.
Republicans should "get past the glib one-liners, the beating up of the media, which is always popular with conservatives," Santorum said.
Democratic strategist Karen Finney said the Republicans' random list of friends and foes has emerged as candidates "try to pick off pieces of the Republican electorate" with very targeted appeals that will add up to an overall win in each primary or caucus state.
"The narrative is shifting based on the audiences they're speaking to," she said.
"There's always, `Who's the good guy and who's the bad guy,'" she said.
In this campaign, that lineup changes every day.
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